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Steven Skube,MD,FACS

Primary Service
  • General Surgery

Areas of Interest

Minimally invasive surgery, robotic surgery, colon cancer, hernia surgery, endocrine surgery, Outcomes research, healthcare disparities, surgical informatics, surgical education, medical student education, rural surgery training, hiatal hernia repair, complex abdominal wall reconstruction, breast cancer, melanoma

  • Undergrad: Bachelor of Science in Business, University of Minnesota, Minneapolis, MN
Medical School
  • Doctor of Medicine, University of Minnesota, Minneapolis, MN
  • General Surgery Residency, University of Minnesota, Minneapolis, MN
  • Surgical Education Research Fellowship, Association for Surgical Education, Minneapolis, MN

Board certification
Surgery, American Board of Surgery

Philosophy of care
My goal is to provide patients with the information they need to understand their medical conditions, to deliver outstanding surgical care, and to offer personal support from diagnosis to recovery.

Why Dr. Skube went into medicine
I initially became interested in medicine to address rural and urban disparities in healthcare. Once I gained some medical experience, I was immediately drawn to surgery and the process of developing a relationship with a patient from the initial diagnosis, through surgery, to recovery. I still maintain an interest in healthcare disparities and am interested in rural surgery education and rural community outreach.

Favorite advice to give patients
Keep up the good work! Take recovery one day at a time.

Virginia, MN

I enjoy spending time with my wife and three children, running, playing tennis, fishing, hunting, and traveling.

Additional languages
Conversational Spanish

Surgical Education Research Fellow, 2017 - 2018
Center for Healthy African American Men through Partnerships Disparity Scholar, 2016 - 2017


Skube SJ, Hu Z, Simon GJ, Wick EC, Arsoniadis EG, Ko CY, Melton GB. Accelerating Surgical Site Infection Abstraction with a Semi-Automated Machine-Learning Approach. Annals of Surgery. In Press.

Skube SJ, Tignanelli CJ, Brunsvold ME. Gangrenous Cholecystitis with Perforation after Transarterial Chemoembolization. Minnesota Medicine. January/February 2020; 41-43.

Skube SJ, Thorndal N, Boulger JG, Clark K, Coverdill J, Chipman JG, Termuhlen PM, Acton RD. Outcomes and Influences of Rural Focused-Focused Integrated Clerkship Programs in General Surgery. American Journal of Surgery. 2020; epub ahead of print.

Arsoniadis, EG, Olson RK, Skube SJ, Marquard J, Melton GB. Resident-Physician Preferences for Electronic Handoff Note Content: Implications for Implementation of a System-Wide Electronic Health Record-Integrated Handoff Tool. Stud Health Technol Inform. 2019 Aug 21;264:1121-1125.

Skube SJ, Ramaswamy A, Chipman JG, Acton RD. Medical Student Perceptions of 24-Hour Call. J Surg Educ. 2019;76:387-392.

Mercier P/Skube SJ, Leonard S, McElroy A, Goettl T, Najarian M, Termuhlen PM, Chipman JG. Creating a Rural Surgery Track and a Review of Rural Surgery Training. J Surg Educ. 2019;76:459-468.

Skube SJ, Arsoniadis EG, Sulciner ML, Gilles SR, Gaertner WB, Madoff RD, Melton GB, Kwaan MR. Colorectal lymphoma: a contemporary case series. Diseases of the Colon & Rectum. 2019 Jun;62(6):694-702.

Skube SJ, Lindgren B, Fan Y, Jarosek S, Melton GB, McGonigal MD, Kwaan MR. Penetrating Colon Trauma Outcomes in Black and White Men. American Journal of Preventative Medicine. 2018;55:S5-S13.

Taylor L, Adkins S, Hoel A, Hauser J, Suwanabol P, Wood G, Anderson W, Branson C, Skube SJ, Johnson S, Zelenski A, Tucholka J, Campbell T, Schwarze M. Using Implementation Science to Adapt a Training Program to Assist Surgeons with High-Stakes Communication. J Surg Educ. 2018;76:165-173.

Skube SJ, Arsoniadis EG, Jahansouz C, Novitsky S, Chipman JG. Supplementing Resident Research Funding through a Partnership with Local Industry. J Surg Educ. 2018;75:907-910.

Skube SJ, Lindemann EA, Arsoniadis EG, Akre M, Wick EC, Melton GB. Characterizing Functional Health Status of Surgical Patients in Clinical Notes. American Medical Informatics Association Informatics Summit Proceedings. 2018: 379-388.

Hultman G, McEwan R, Skube SJ, Melton GB. Usability Testing of an Unstructured Clinical Document Query Tool for Researchers. American Medical Informatics Association Informatics Summit Proceedings. 2018: 84-93.

Skube SJ, Katz SA, Chipman JG, Tignanelli CJ. Acute Kidney Injury and Sepsis. Surg Infect (Larchmt). 2018;19(2):216-24.

Sun D, Sarda G, Skube SJ, Blaes AH, Melton GB, Simon GJ, Zhang R. Causal Phenotyping for Susceptibility to Cardiotoxicity from Antineoplastic Breast Cancer Medications. American Medical Informatics Association Annual Symposium Proceedings. 2017: 1655-1664.

Lindemann EA, Chen ES, Wang Y, Skube SJ, Melton GB. Representation of Social History Factors Across Age Groups: A Topic Analysis of Free Text Social Documentation. American Medical Informatics Association Annual Symposium Proceedings. 2017: 1169-1178.

Skube SJ, Hu Z, Arsoniadis EG, Simon GJ, Wick EC, Ko CY, et al. Characterizing Surgical Site Infection Signals in Clinical Notes. Stud Health Technol Inform. 2017;245:955-9.

Arsoniadis EG, Skube SJ, Bjerke TM, Jarabek B, Melton GB. Assessing Provider-Generated Free-Text Quality in EHR-Integrated Handoff Notes. Stud Health Technol Inform. 2017;245:999-1003.

Sun D, Sarda G, Skube SJ, Blaes AH, Khairat S, Melton GB, et al. Phenotyping and Visualizing Infusion-Related Reactions for Breast Cancer Patients. Stud Health Technol Inform. 2017;245:599-603.

Hultman G, McEwan R, Pakhomov S, Lindemann E, Skube SJ, Melton GB. Usability Testing of NLP-PIER, Natural Language Processing Patient Information Extraction for Research. Stud Health Technol Inform. 2017; 245: 1269.

Lee JT, Skube S, Melton GB, Kwaan MR, Jensen CC, Madoff RD, et al. Elective Colectomy for Diverticulitis in Transplant Patients: Is It Worth the Risk? J Gastrointest Surg. 2017;21(9):1486-90.

Sun D, Sarda G, Skube SJ, Blaes A, Zhang R, Melton GB. A Study on Phenotyping and Visualizing Black Box Warnings of Antineoplastic Breast Cancer Medications. American Medical Informatics Association Joint Summits Translational Science Proceedings. 2017: 392-393.

Hultman G, McEwan R, Pakhomov S, Skube SJ, Melton GB. Usability Testing of a Clinical Document Search Engine for Researchers. American Medical Informatics Association Joint Summits Translational Science Proceedings. 2017: 348-349.

Oliveira AR, Beyer G, Chugh R, Skube SJ, Majumder K, Banjeree S, Sangwan V, Li L, Dawra RK, Subramanian S, Saluja AK, Dudeja V. Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F. Laboratory Investigation, 2015 Jun;95(6):648-59

Westra R, Skube S, Zant M. HOPE Clinic: A Place to Care. Minnesota Medicine, November 2011, 94(11); 45-51.

Dudeja V, Chugh RK, Sangwan V, Skube SJ, Mujumdar NR, Antonoff MB, Dawra RK, Vickers SM, Saluja AK. Pro-survival Role of Heat Shock Factor 1 (HSF1) in the Pathogenesis of PancreatoBiliary Tumors. American Journal of Gastrointestinal and Liver Physiology Jun; 300(6):G948-55.

Antonoff MB, Chugh R, Skube SJ, Dudeja V, Borja-Cacho D, Clawson KA, Vickers SM, Saluja AK, Role of Hsp-70 in Triptolide-Mediated Cell Death of Neuroblastoma. Journal of Surgical Research 2010; 163: 72–78.

Antonoff MB, Chugh R, Borja-Cacho D, Dudeja V, Clawson KA, Skube SJ, Sorenson BS, Saltzman DA, Vickers SM, Saluja AK. Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo. Surgery. 2009 Aug; 146(2):282-90