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Basem Goueli, MD, PhD

(218) 249-3081
Basem Goueli MD, PhD
Primary Specialties
  • Oncology and Hematology
     (Board Certified)
  • Secondary Specialties
  • Internal Medicine
     (Board Certified)
  • St. Luke's Oncology & Hematology Associates
    1001 East Superior Street, Suite 101
    St. Luke's Lakeview Building
    Duluth, MN 55802

    Education

    Bachelor's Degree (double major) - University of Minnesota, Minneapolis, Minnesota
    Medical School - Mayo Clinic Medical College, Rochester, Minnesota
    Graduate School (Ph.D in Biochemistry) - Mayo Clinic Medical College, Rochester, Minnesota
    Residency - George Washington University, Washington, DC (Internal Medicine), and the National Institutes of Health, Bethesda, Maryland
    Clinical Fellowship - Stanford University, Palo Alto, California (Hematology and Medical Oncology)
    Postdoctoral Research Fellowship (Biochemistry) - Stanford University, Palo Alto, California

    Experience

    Publications
    Oncology and Hematology
    Internal Medicine

    Bio

    Dr. Basem Goueli is the director of St. Luke's Regional Cancer Center. He received his MD/Ph.D at the Mayo Clinic Medical College in Rochester, Minnesota. He completed his internal medicine residency at George Washington University in Washington, DC, where he spent several months training at the National Institutes of Health. Subsequently, he did his fellowship in hematology and medical oncology at Stanford University in Palo Alto, California. During that time he was awarded the Stanford Cancer Institute DCRA award and the highly prestigious American Cancer Society Postdoctoral Fellowship. To date, he is the first author on six scientific publications, the most recent of which was published in the Proceedings of the National Academy of Sciences in September 2012.

    Dr. Goueli is a professor at the University of Minnesota Medical School, Duluth, where he conducts laboratory-based cancer research. He works with the Whiteside Institute for Clinical Research to bring clinical trials to St. Luke's Regional Cancer Center to provide patients with the best treatment options possible, as he is dedicated to ensuring that St. Luke's patients receive the highest standard of care. He is board certified in internal medicine, hematology and medical oncology.

    Dr. Goueli was part of a research team which had an article published in the May 9, 2013, edition of the New England Journal of Medicine. The article, entitled 'Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML', can be read in full here: http://www.nejm.org/doi/full/10.1056/NEJMoa1214514

    He currently is on the state board for the American Cancer Society.

    In his first year of eligibility, Dr. Goueli was named by his peers as one of Duluth's top doctors in 2013. In 2015, Dr. Goueli was named one of the "20 under 40" by the Duluth News Tribune.

    Dr. Goueli was interviewed for the March/April 2015 issue of the Duluthian magazine. The article, "Clinical Trials Help Advance Cancer Treatment at St. Luke’s Regional Cancer Center," is available online.

    In his spare time, Dr. Goueli enjoys spending every minute he can with his wife, Iman, and their twin boys. He tries to be as well-rounded as possible. He is an avid weightlifter and enjoys playing numerous sports, including soccer, tennis and basketball. He enjoys writing and at the present time is taking guitar, piano and vocal lessons. He likes movies (“Shawshank Redemption” is his favorite), music (he's been to innumerable concerts) and watching sports.

    Publications

    Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW. 2013. "Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML." N Engl J Med 368(19), 1781-90.

    Goueli BS, Powell M, Finger EC, and Pfeffer SR. 2012. "TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling ." Proc Natl Acad Sci USA 109(39), 15787-92.

    Goueli BS and Janknecht R. 2004. "Upregulation of the Catalytic Telomerase Subunit by the transcription factor ER81 and Oncogenic HER2/Neu, Ras, or Raf." Mol Cell Biol 24(1), 25-35.

    Goueli BS and Janknecht R. 2003. "Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor." Oncogene 22 (39), 8042-8047.

    Bosc DG, Goueli BS, and Janknecht R. 2001. "Her2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1." Oncogene 20 (43), 6215-6224.

    Goueli BS, Hsiao K, and Goueli SA. 2001. "Assaying activity of individual protein kinases in crude tissue or cellular extracts." Methods Enzymol 333, 16-27.

    Goueli BS, Hsiao K, and Goueli SA. 2001. "A novel and simple method to assay the activity of individual protein kinases in a crude tissue extract." Methods Mol Med 39, 633-44.

    Goueli BS, Hsiao K, Tereba A, and Goueli SA. 1995. "A novel and simple method to assay the activity of individual protein kinases in a crude tissue extract." Anal Biochem 225(1), 10-17.

    Recent Grants

    April 2012: Awarded the American Cancer Society Postdoctoral Fellowship (July 2012-June 2015, $150,000) for the project, "Elucidation of the role of TBC1D16 in Melanomagenesis." (Could not accept the award due to starting as the medical director of St. Luke's Regional Cancer Center)

    August 2011: Awarded the DCRA Interdisciplinary Grant by the Stanford University Cancer Institute (September 2011-August 2012, $50,000) for the project, "Elucidation of the role of TBC1D16 in Melanomagenesis."

    Teaching

    2013: Immunology/Hematology/Oncology - University of Minnesota Medical School, Duluth: First Year Medical School Course (six lectures): Generation of Reactive Oxygen Species and Reactive Nitrogen Oxygen Species; Antioxidants; Plasma Composition and Red Blood Cell Metabolism; Iron Metabolism; Heme Metabolism; The Biochemistry of Hemostasis.

    2014: Immunology/Hematology/Oncology - University of Minnesota Medical School, Duluth: First Year Medical School Course (six lectures): Generation of Reactive Oxygen Species and Reactive Nitrogen Oxygen Species; Antioxidants; Plasma Composition and Red Blood Cell Metabolism; Iron Metabolism; Heme Metabolism; The Biochemistry of Hemostasis.

    2015: Immunology/Hematology/Oncology - University of Minnesota Medical School, Duluth: First Year Medical School Course (six lectures): Generation of Reactive Oxygen Species and Reactive Nitrogen Oxygen Species; Antioxidants; Plasma Composition and Red Blood Cell Metabolism; Iron Metabolism; Heme Metabolism; The Biochemistry of Hemostasis.

    Speeches

    Dr. Goueli recently gave a speech titled, "Behind the Curtain: A Never-Before Seen Look at Cancer Survivorship" as part of St. Luke's Understanding Cancer: Survivorship Lecture Series to over 250 attendees.Click the link above to view the entire lecture.

    Clinical Interests/Expertise

    Clinical cancer trials, therapeutic response profiling in solid tumors, signal transduction in oncogenesis, drug development.

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